Mechanisms of deep brain stimulation
Identifieur interne : 004390 ( Main/Exploration ); précédent : 004389; suivant : 004391Mechanisms of deep brain stimulation
Auteurs : Alim-Louis Benabid [France] ; Abdelhamid Benazzous [France] ; Pierre Pollak [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2002-03.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- MESH :
- physiology : Neurons.
- therapy : Movement Disorders.
- Animals, Electric Stimulation Therapy, Humans.
Abstract
The mechanism of action of high frequency deep brain stimulation is still unknown. However, in all circumstances and in all target nuclei so far stimulated, the effects mimic those of lesions previously made during thalamotomies, pallidotomies or even subthalamotomies, suggesting an inhibition of at least the neuronal network containing the target, if not of the target itself. On the contrary, fiber bundles are consistently activated at low or high frequencies. The hypothetical mechanisms envisioned should therefore be compatible and even produce these observed effects, to be acceptable as hypotheses. The mechanism could be either one or a combination of several causes: jamming of a feedback loop, activation of inhibitory structures included in a more complex network, blockade of membrane ion channels, deplorisation blockade, synaptic exhaustion, induction of early genes, changes in local blood flow, neuroplasticity, etc. It is probable that some are more involved in the acute effects and others in the long term changes, close to neuroplasticity. It is clear that the understanding of this strange and powerful phenomenon will profit from both clinical observation and well designed animal experiments. © 2002 Movement Disorder Society
Url:
DOI: 10.1002/mds.10145
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002E84
- to stream Istex, to step Curation: 002E84
- to stream Istex, to step Checkpoint: 002C81
- to stream Main, to step Merge: 006395
- to stream PascalFrancis, to step Corpus: 002811
- to stream PascalFrancis, to step Curation: 000510
- to stream PascalFrancis, to step Checkpoint: 002695
- to stream Main, to step Merge: 006734
- to stream PubMed, to step Corpus: 003A91
- to stream PubMed, to step Curation: 003A91
- to stream PubMed, to step Checkpoint: 003A27
- to stream Ncbi, to step Merge: 000760
- to stream Ncbi, to step Curation: 000760
- to stream Ncbi, to step Checkpoint: 000760
- to stream Main, to step Merge: 006168
- to stream Main, to step Curation: 004390
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mechanisms of deep brain stimulation</title><author><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim-Louis Benabid</name><affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author><author><name sortKey="Benazzous, Abdelhamid" sort="Benazzous, Abdelhamid" uniqKey="Benazzous A" first="Abdelhamid" last="Benazzous">Abdelhamid Benazzous</name></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:03100AFB706FB879CD4D15F4B7354986DC0596BE</idno><date when="2002" year="2002">2002</date><idno type="doi">10.1002/mds.10145</idno><idno type="url">https://api.istex.fr/document/03100AFB706FB879CD4D15F4B7354986DC0596BE/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002E84</idno><idno type="wicri:Area/Istex/Curation">002E84</idno><idno type="wicri:Area/Istex/Checkpoint">002C81</idno><idno type="wicri:doubleKey">0885-3185:2002:Benabid A:mechanisms:of:deep</idno><idno type="wicri:Area/Main/Merge">006395</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:02-0309270</idno><idno type="wicri:Area/PascalFrancis/Corpus">002811</idno><idno type="wicri:Area/PascalFrancis/Curation">000510</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002695</idno><idno type="wicri:doubleKey">0885-3185:2002:Benabid A:mechanisms:of:deep</idno><idno type="wicri:Area/Main/Merge">006734</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:11948758</idno><idno type="wicri:Area/PubMed/Corpus">003A91</idno><idno type="wicri:Area/PubMed/Curation">003A91</idno><idno type="wicri:Area/PubMed/Checkpoint">003A27</idno><idno type="wicri:Area/Ncbi/Merge">000760</idno><idno type="wicri:Area/Ncbi/Curation">000760</idno><idno type="wicri:Area/Ncbi/Checkpoint">000760</idno><idno type="wicri:doubleKey">0885-3185:2002:Benabid A:mechanisms:of:deep</idno><idno type="wicri:Area/Main/Merge">006168</idno><idno type="wicri:Area/Main/Curation">004390</idno><idno type="wicri:Area/Main/Exploration">004390</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Mechanisms of deep brain stimulation</title><author><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim-Louis Benabid</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Neurosciences Department, Joseph Fourier University, Centre Hospitalier Universitaire, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author><author><name sortKey="Benazzous, Abdelhamid" sort="Benazzous, Abdelhamid" uniqKey="Benazzous A" first="Abdelhamid" last="Benazzous">Abdelhamid Benazzous</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Neurosciences Department, Joseph Fourier University, Centre Hospitalier Universitaire, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Neurosciences Department, Joseph Fourier University, Centre Hospitalier Universitaire, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement></placeName><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2002-03">2002-03</date><biblScope unit="vol">17</biblScope><biblScope unit="issue">S3</biblScope><biblScope unit="supplement">3</biblScope><biblScope unit="page" from="S73">S73</biblScope><biblScope unit="page" to="S74">S74</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">03100AFB706FB879CD4D15F4B7354986DC0596BE</idno><idno type="DOI">10.1002/mds.10145</idno><idno type="ArticleID">MDS10145</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brain (vertebrata)</term><term>Electric Stimulation Therapy</term><term>Human</term><term>Humans</term><term>Instrumental stimulation</term><term>Mechanism of action</term><term>Movement Disorders (therapy)</term><term>Neurons (physiology)</term><term>Treatment</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Electric Stimulation Therapy</term><term>Humans</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Encéphale</term><term>Homme</term><term>Mécanisme action</term><term>Stimulation instrumentale</term><term>Traitement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The mechanism of action of high frequency deep brain stimulation is still unknown. However, in all circumstances and in all target nuclei so far stimulated, the effects mimic those of lesions previously made during thalamotomies, pallidotomies or even subthalamotomies, suggesting an inhibition of at least the neuronal network containing the target, if not of the target itself. On the contrary, fiber bundles are consistently activated at low or high frequencies. The hypothetical mechanisms envisioned should therefore be compatible and even produce these observed effects, to be acceptable as hypotheses. The mechanism could be either one or a combination of several causes: jamming of a feedback loop, activation of inhibitory structures included in a more complex network, blockade of membrane ion channels, deplorisation blockade, synaptic exhaustion, induction of early genes, changes in local blood flow, neuroplasticity, etc. It is probable that some are more involved in the acute effects and others in the long term changes, close to neuroplasticity. It is clear that the understanding of this strange and powerful phenomenon will profit from both clinical observation and well designed animal experiments. © 2002 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Grenoble</li></settlement><orgName><li>Centre hospitalier universitaire Grenoble Alpes</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim-Louis Benabid</name></noRegion><name sortKey="Benazzous, Abdelhamid" sort="Benazzous, Abdelhamid" uniqKey="Benazzous A" first="Abdelhamid" last="Benazzous">Abdelhamid Benazzous</name><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004390 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004390 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:03100AFB706FB879CD4D15F4B7354986DC0596BE
|texte= Mechanisms of deep brain stimulation
}}
| This area was generated with Dilib version V0.6.23. |  |